Bakson has always worked to deliver the best without compromising on quality. We take due care of the raw material and sophisticated processes involved at each step for manufacturing unmatched homoeopathic products.
The enviable mountainous location in Himalayan foothills of our modern plant at Parwanoo (H.P.) enables an easy access to main raw materials i.e. medicinal herbs of the highest quality, which is reflected in our finished products. Provings by Hahnemann and other authorities have been carried out on herbs, which were mostly naturally available. It is clear that change of climate, soil, area of cultivation, crossbreeding (whether natural or manipulated) gives rise to plants, which may be of a different species from others even though morphologically the genus may be the same. That is why it has been our constant effort to obtain the herbs in their most natural forms and to get only the appropriate species. Hence, we import many herbs from the countries of their original habitat.
At Bakson we use the best known E.N.A i.e. Extra Neutral Alcohol in Mother Tinctures, Dilutions and Specialities. This ensures the purity, pleasant taste & odour of an essential medium with which the higher energies of the dynamized medicines are carried over & as a whole, purity of all our finished products. In fact, we have consumed 3.15lac litres of E.N.A. in the year 2004-05 & thus are the largest consumer of E.N.A. in Asia. We strictly carry out qualitative limit tests to check the presence of higher aldehydes, higher ketones, fusel oils and other harmful impurities in alcohol, thus matching the exact specification of Homoeopathic Pharmacopoeia of India.
Lactose forms the basis of homoeopathic triturations, hence it becomes imperative to take apt quality control measures to ensure a strong base for all subsequent preparations. Bakson utilizes pharmaceutical-grade, high-class lactose as per the standards of identity and purity, set down in the lactose monographs of HPI. To assure a regular and homogeneous lactose supply, we import it from Hilmar Cheese Company located in California’s Central Valley.
STANDARDIZATION OF HERBS
The new procured herb is tested in the Bakson Drugs & Pharmaceuticals’ Laboratory and simultaneously sent to government approved labs. besides Homoeopathic Pharmacopoeia Laboratory, India. The approved sample’s specifications are followed to define and label the control sample of drug, which is used for reference in future.
Control Sample features are followed as per standard homoeopathic pharmacopoeias to identify the sample lot of new drug. These include part of plant to be used, morphology, adulterants, maturity and age of the herb besides ruling out possibility of any substitutes.
This is followed by checking of Histological and Morphological features of the herbs through already prepared permanent slides of control samples (both longitudinal and transverse sections).
After proper identification manufacture of Mother Tinctures is done as per the guidelines of Standard Homoeopathic Pharmacopoeias. The final product is then tested as regards its colour, odour, pH, total solids and alcohol content to meet the required specifications. The mother tinctures thus prepared are then subjected to Thin Layer Chromatography and UV Spectrophotometry to determine their quality compliance on basis of defined parameters.
THIN LAYER CHROMATOGRAPHY (TLC) is a simple, quick, and inexpensive procedure that gives a quick answer as to how many components are in a mixture. TLC is also used to support the identity of a compound in a mixture when the Rf of a compound is compared with the Rf of a known compound (preferably both run on the same TLC plate). Rf is the retention factor, or how far up a plate the compound travels.
UV SPECTROPHOTOMETRY is used to perform quality control assays on drug substances obtained from different sources in order to compare their spectra with that of our standard spectrum for the same drug substance.
HPTLC (High Performance Thin Layer Chromatography) is a sophisticated and automated form of TLC. The procedure simultaneously processes the sample and standard that results in better analytical precision and accuracy at a faster pace. It allows several analysis to be done at the same time. The exclusive features of HPTLC include:
- Simple sample preparation - handle samples of divergent nature
- No prior treatment for solvents like filtration and degassing
- Low mobile phase consumption per sample
- No interference from previous analysis - fresh stationary and mobile phases for each analysis - no contamination
- Visual detection possible - open system
- Non UV absorbing compounds detected by post-chromatographic derivatization
The steps involved in HPTLC are as follows:
- Selection of chromatographic layer
- Sample and standard preparation
- Layer pre-washing
- Layer pre-conditioning
- Application of sample and standard
- Chromatographic development
- Detection of spots
- Documentation of chromatic plate
|Keeping abreast with the latest & high-precision technology, Bakson has incorporated the use of ‘Automatic Potentizer’ to ensure standardized dynamisation of higher potencies.
- It is an easy to operate equipment that enables to raise 900 potencies per head in one time operation.
- The calibrated potentizer operates as per the specifications of homoeopathic pharmacopoeia & can replace infinity manual working hours.
- The contact parts made of SS-316 make the operation hygienic.
- The operation stops automatically after a prefixed number of cycles & retains the data in memory, in case of power failure to restart the process from where it was shut off.
All the above procedures practiced at Bakson Drugs & Pharmaceuticals project the meticulous operative and standardization processes involved in assuring that the right kind of herb is used to produce safe and effective Homoeopathic Medicines.
LAMINAR AIR FLOW
At Bakson, considering the requisite sterilized settings to overcome even infinitesimal chances of particulate contamination, the concept of laminar air flow is adopted. Room air is taken into the unit and passed through a pre-filter to remove gross contaminants (lint, dust etc). The air is then compressed and channeled up behind and through the HEPA filter (High Efficiency Particulate Air filter) in a laminar flow fashion--that is the purified air flows out over the entire work surface in parallel lines at a uniform velocity. The HEPA filter removes nearly all of the bacteria from the air and assures uncontaminated surroundings in the sections of preparation & packaging of medicines.
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